The Hampton Inn Grand Junction CO hotel, on historic Main Street in downtown Grand Junction, Colorado, enjoys a prime location that allows guests to stroll past 150 shops, restaurants, museum and theatres. Adjacent to our Hampton Inn hotel is the Two River Convention Center with over 29,000 square feet of meeting and banquet space. City, state and federal offices are located downtown near our Hampton Inn hotel. Visitors to the Grand Junction area enjoy activities such as biking and walking. Colorado's wine country is found just minutes from the hotel where tours and wine tastings are available from over a dozen wineries year round. We love having you here in Colorado at the Hampton Inn Grand Junction CO hotel!